We are truly sorry to hear about the trials you've been facing, especially the loss of your sister. It is so important if you are a believer in Jesus Christ that you have hope in His salvation and the power of the resurrection. It is only by His name that we have access to God, as it is written, "For there is one God, and one mediator between God and men, the man Christ Jesus", and also in Acts 4:12, "There is salvation in none other, for neither is there any other name under heaven, that is given among men, wherever we must be saved." Therefore it is so important we go to God in Jesus name. God is loving and merciful, and in Jesus name we can petition for His help. Jesus Christ Himself said, "Come to me, all you who labor and are heavily burdened, and I will give you rest." In this life, we will have much trouble and trials but we need to know Jesus Christ has overcome the world.
In your current situation, it's understandable that you feel exhausted, unhappy, and even trapped. However, we want to encourage you with the words of Psalm 34:18, "Yahweh is near to those who have a broken heart, and saves those who have a crushed spirit." God is with you in your suffering, and He cares about your pain.
Regarding your illnesses, remember that our bodies are temples of the Holy Spirit. It is so true that our spirits are strong but our bodies are weak. We should be praying for the Lord's healing for your physical and mental illnesses. We can claim the power of Jesus Christ in His suffering and sacrifice on the cross for our healing. You can look at many wonderful healings by Jesus Christ: the woman that touched the hem of his garment, the blind man, the lepers, and the blind man that washed in the pool of Siloam. We can look at these examples and know that it is only by the power of Jesus Christ that we can be healed. We need to look to Jesus Christ. Let us pray for your healing and recovery.
Concerning your desire to move, we advise that you should trust in God's timing. While it's natural to want a change of scenery, especially when facing difficulties, it's crucial to seek God's will in the matter. We would also add if you can't change your location, you can change your situation by making your home a place of happiness and contentment. Remember that God can turn any situation around for your good, as it is written, "We know that all things work together for good for those who love God, to those who are called according to his purpose."
Let us pray together:
Dear Father, we come before You, lifting up our ### in her distress. We ask You to surround her with Your love and comfort, and to grant her Your supernatural peace and strength. Heal her from her illnesses, both physical and mental, and help her to trust in Your perfect plan for her life. Guide her in her desires, and if it is Your will, provide a way for her to move to a new home. Give her a renewed hope and joy in her heart and bring her laughter instead of tears. We ask this in Jesus Name. Amen.
Be strong and of good courage, and let the joy of the Lord be your strength. God loves you more than you can comprehend and His thoughts towards us are more than the grains of sand on the seashore.
Prayer Focus: God, Thank You. Thank You for loving me. God, I ask You in Jesus’ name bless me with everything that I stand in need of and everything You want me to have. Bless me to know You in truth, fall in love with You with all my heart, mind, soul, body, and strength and never fall out of love with You. Bless me to have an ever growing closer stronger, more intimate relationship with You. Bless me with the love, desire, strength, and the spirit of obedience to always delight myself in You, seek first Your kingdom, and Your righteousness. Help and strengthen me God to always respect and obey You. Bless me to trust You with all my heart, acknowledge You in all my ways, and lean not to my own understanding. 
