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Thanks.Reading the entire chapter and getting the overall meaning in context of the verses surrounding the verse will make a difference.
The verse stresses our dedication to the Lord is the priority and pleasing Him instead of pleasing human biological family we were born into.
Also, in view of Mark 12:30-31 Love is the most important commandment which also sheds light on the verse you mentioned. Matthew 5:44 Jesus tells us to love our enemies and pray for those who persecute you.
Isolating a verse can result in misinterpretation. Viewing obscure in light of the themes that are mentioned over and over is important. The word Love shows up 759 times in the New Testament, the word enemy shows up significantly less number of times 171. It is logical to concentrate on what the themes bible focuses on.
..."love the Lord your God with all your heart, all your soul, all your mind, and all your strength.’ The second is equally important: ‘Love your neighbor as yourself. No other commandment is greater than these" (Mark12:30-31)